Trimethoxine 1L
Triméthoprime -
Sulfadimethoxine
Solution Orale
Flacons de 100mL & 1L

** COMPOSITION : **

Trimethoprim…………………………………4g Sulfadiazine………………………………….20g Benzyl alcohol…………………………….1ml Excipient q.s.p……………………………..1L

** PROPERTIES : **

Synergistic bactericidal association of trimethoprim and sulfadiazine. TRIMETHOZINE has a broad spectrum of activity against Gram (+) and Gram (-) bacteria.

** DIRECTIONS: **

In cattle, pigs, sheep, horses, poultry and rabbits: Diseases caused by germs sensitive to the sulfadiazine and trimethoprim combination, in particular infections of the respiratory and genito-urinary systems.

** ADMINISTRATION AND DOSAGE: **

Orally, in liquid food or drinking water: - Poultry and rabbits: 4 ml per 10 liters of drinking water per day for 5 to 7 days. - Cattle, pigs, horses, sheep: 5 ml for 80 to 100 kg of live weight and per day for 5 to 7 days.

** CONTRAINDICATIONS: **

Do not administer to laying poultry whose eggs are intended for human consumption.

** WAITING TIME : **

Meat : -Rabbits, cattle, pigs, sheep and horses: 10 days / Poultry: 5 days -Milk: 96 hours

** PHARMACODYNAMIC PROPERTIES: **

-Sulfadiazine is a long-acting sulfonamide with a broad spectrum of activity. It is active against Gram positive and Gram negative bacteria. Trimethoprim belongs to the diaminopyrimidine family. It is active against streptococci and most Gram-negative bacteria. – In combination, these two active ingredients are synergistic.

– The combination of these two active ingredients allows a sequential blocking of the biosynthesis of folic acid: sulphonamide by inhibiting the incorporation of para-aminobenzoic acid into folic acid, trimethoprim by specifically inhibiting microbial dehydrofolate reductase .

– The theoretical activity spectrum extends to both Gram-positive germs (Staphylococcus, Listeria, etc.) and Gram-negative germs (Escherichia coli, Salmonella, Proteus, Enterobacter, Bordetella, etc.).

** PHARMACOKINETIC CHARACTERISTICS: **

Sulfadiazine is considered a half-acting sulfonamide with a fairly long persistence of plasma levels. Its binding to plasma proteins is important. Distribution is good in most tissues and organs. Trimethoprim is rapidly absorbed after oral administration. It is widely distributed in the body. Both active ingredients are partially metabolized in the liver. Their elimination is essentially renal.

** CONSERVATION : **

Store away from light and humidity.

Créés en 1995, les laboratoires AFRIMED développent, fabriquent, et commercialisent en Tunisie et à l’international des médicaments et des compléments nutritionnels répondants aux besoins des vétérinaires, des éleveurs et des propriétaires d’animaux de compagnie.

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AFRIMED S.A. BP 76 Route de Sousse 5012 Sahline – TUNISIE

(+216) 73 52 52 01

(+216) 73 52 52 03

Contact@afrimed.net